Newcastle, Brentford, Man United and West Ham are all in action.
Two other clubs with Champions League ambitions are in action tonight.
Manchester United, who lie fifth, host Brentford at Old Trafford.
Casemiro remains suspended for Man United, who have failed to win any of their last three Premier League games.
Third placed Newcastle United go to the London Stadium to play West Ham United.
Both of those matches kick off at 8pm.

Declan Rice Among The Absentees For Arsenal This Evening
Wednesday Morning Sports Update
Celtic Legend John 'Dixie' Deans Has Died
Craig Casey Signs Two Year Contract Extension With Munster
Today's Fixture At Punchestown Cancelled Due To Storm Bram
Tuesday Morning Sports Update
Former Jockey Rachael Blackmore Receives Contribution To The Industry Award At 2025 Horse Racing Ireland Awards
Club Decision Sees Mohamed Salah Dropped For Champions League Trip To Milan